2021 National Southern League
| Rk | Name | gp | rush | yds | y/g | avg | td | lg | fum | lost | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | C Galban | Fullerton | 10 | 95 | 192 | 19.2 | 2.0 | 4 | 41 | 7 | 4 |
| 2 | G Gray | San Diego Mesa | 11 | 29 | -143 | -13.0 | -4.9 | 2 | 16 | 5 | 3 |
| 3 | A Bacher | San Bernardino Valley | 10 | 160 | 844 | 84.4 | 5.3 | 6 | 54 | 3 | 2 |
| 3 | K Davis | Southwestern | 9 | 33 | 71 | 7.9 | 2.2 | 1 | 13 | 3 | 2 |
| 3 | R Eggleston | San Bernardino Valley | 7 | 26 | -43 | -6.1 | -1.7 | 0 | 10 | 4 | 2 |
| 3 | C Justice | San Bernardino Valley | 6 | 35 | -89 | -14.8 | -2.5 | 1 | 20 | 3 | 2 |
| 3 | D Nash | Saddleback | 8 | 37 | 36 | 4.5 | 1.0 | 2 | 13 | 3 | 2 |
| 3 | K Perez | San Bernardino Valley | 3 | 6 | 8 | 2.7 | 1.3 | 0 | 14 | 2 | 2 |
| 3 | B Rankins | Fullerton | 10 | 141 | 721 | 72.1 | 5.1 | 12 | 98 | 3 | 2 |
| 10 | A Ashley | Saddleback | 10 | 43 | 204 | 20.4 | 4.7 | 3 | 42 | 2 | 1 |
| 10 | R Black | Fullerton | 7 | 27 | 179 | 25.6 | 6.6 | 3 | 60 | 1 | 1 |
| 10 | M Blackney | Fullerton | 5 | 8 | 37 | 7.4 | 4.6 | 0 | 10 | 1 | 1 |
| 10 | J Calhoun | San Bernardino Valley | 8 | 1 | -2 | -0.3 | -2.0 | 0 | 0 | 1 | 1 |
| 10 | M Carrillo | Golden West | 10 | 82 | 389 | 38.9 | 4.7 | 4 | 27 | 1 | 1 |
| 10 | T Edwards | Fullerton | 8 | 52 | 245 | 30.6 | 4.7 | 3 | 37 | 1 | 1 |
| 10 | S Hicks | Saddleback | 10 | 13 | 28 | 2.8 | 2.2 | 1 | 15 | 1 | 1 |
| 10 | J Inman | Southwestern | 8 | 30 | -20 | -2.5 | -0.7 | 0 | 13 | 1 | 1 |
| 10 | J Johnson | Golden West | 12 | 72 | 330 | 27.5 | 4.6 | 2 | 18 | 1 | 1 |
| 10 | C Patterson | San Diego Mesa | 11 | 129 | 549 | 49.9 | 4.3 | 5 | 51 | 3 | 1 |
| 10 | D Ralph | Saddleback | 8 | 38 | 84 | 10.5 | 2.2 | 3 | 18 | 1 | 1 |
| 10 | J Retzlaff | Golden West | 12 | 90 | 380 | 31.7 | 4.2 | 9 | 51 | 5 | 1 |
| 10 | A Robinson | Southwestern | 9 | 33 | 87 | 9.7 | 2.6 | 2 | 10 | 1 | 1 |
| 10 | D Warren | Southwestern | 9 | 5 | 4 | 0.4 | 0.8 | 0 | 6 | 1 | 1 |
| 10 | A Wimmer | Saddleback | 10 | 130 | 580 | 58.0 | 4.5 | 2 | 73 | 1 | 1 |
| 25 | J Butler | San Diego Mesa | 9 | 81 | 335 | 37.2 | 4.1 | 2 | 21 | 1 | 0 |
| 25 | D Fortune | San Bernardino Valley | 8 | 3 | 4 | 0.5 | 1.3 | 0 | 29 | 1 | 0 |
| 25 | K Griffin | Fullerton | 10 | 2 | 30 | 3.0 | 15.0 | 0 | 17 | 1 | 0 |
| 25 | M Lewis | San Bernardino Valley | 3 | 26 | -12 | -4.0 | -0.5 | 0 | 27 | 1 | 0 |
| 25 | D McCall | San Bernardino Valley | 8 | 1 | -7 | -0.9 | -7.0 | 0 | 0 | 3 | 0 |
| 25 | D Moore | Fullerton | 7 | 34 | 127 | 18.1 | 3.7 | 2 | 20 | 1 | 0 |
| 25 | K Owens | San Bernardino Valley | 4 | 1 | -5 | -1.3 | -5.0 | 0 | 0 | 1 | 0 |
| 25 | N Remigio | Saddleback | 3 | 3 | 27 | 9.0 | 9.0 | 0 | 14 | 1 | 0 |
| 25 | L Staples | San Bernardino Valley | 10 | 1 | 30 | 3.0 | 30.0 | 0 | 30 | 1 | 0 |
